KIDNEY / NEPHROLOGY NEWS

Diabetic amputations on the rise in the U.S.

(Reuters Health) - - A growing number of people with diabetes in the U.S. are losing toes and feet to the disease by the time they reach middle age, according to a study that suggests a reversal after years of progress against diabetes.

Christmas Is a Peak Time for Heart Attacks

In Sweden, Christmas Eve, Christmas Day and New Year’s Day were prime times for heart troubles.

Statins: Risk of side effects is low, say experts

For most people at risk of heart attack and stroke, using statins to lower cholesterol brings more benefits than risks, say the American Heart Association.

Organ donors to be asked if they are religious

It is hoped the measure can boost the low proportion of donors from black and Asian backgrounds.

Kidneys from deceased donors with acute kidney injury suitable for transplant

Organ procurement teams are sometimes leery of accepting kidneys from deceased donors with acute kidney injury (AKI), fearing they will harm the recipients. However, a new study suggests these fears may be unfounded.

Lymphadenectomy Offers No Survival Benefit in Nonmetastatic RCC

Lymph node dissection did not influence overall survival even among patients with clinically positive nodal disease.

Chronic Kidney Disease Burden Increasing in the US

Study implicates growing prevalence of metabolic and dietary risk factors as important contributors to increases in CKD burden.

Ferrokinetics Differ Among Dialysis Modalities

Both hepcidin-25 levels and the hepcidin/ferritin ratio were significantly higher in patients on peritoneal dialysis vs hemodialysis.

STUDY REVEALS FACILITY-LEVEL VARIATIONS IN DIABETIC KIDNEY DISEASE CARE WITHIN THE VA HEALTH SYSTEM

Concerning adherence to certain recommended measures of kidney disease care for veterans with diabetes within the Veterans Affairs Health Care System, there is modest facility-level variation for some measures and larger facility-level variation for others.

Considerations for Transplants From People With HCV to Those Without

The use of direct-acting antiviral agents to treat chronic HCV could allow for transplantation from donors HCV to recipients without the disease.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

What is the normal pH range for urine?

The acidity of urine varies greatly depending on a person’s diet and any medical conditions they may have. In this article, we discuss the normal pH range for urine, and what abnormal test results might mean.

Can D-mannose treat a UTI?

D-mannose is a type of sugar that researchers believe may help treat urinary tract infections (UTIs). Learn more about the studies, conclusions, and possible dosage here.

What are the symptoms of low sodium levels?

Low sodium in the blood can cause confusion, lethargy, and nausea. Treatment depends on the cause. Learn more about low sodium levels, risk factors, prevention and treatment here.

What are the most common causes of pelvic pain in men?

Pelvic pain in men can result from a range of issues, including a hernia, prostatitis, and appendicitis. This pain occurs somewhere between the navel and groin. Treatment depends on the cause and may involve antibiotics. Learn about the most common causes of pelvic pain in men here.

What are bone metastases in prostate cancer?

When prostate cancer spreads to the bones, this is known as bone metastases. Although there is no cure for this advanced stage of prostate cancer, treatment can help relieve symptoms, improve quality of life, and extend life expectancy. Learn more here.

What is lupus?

Lupus is a complex and potentially serious autoimmune condition. It has a variety of symptoms and can affect different parts of the body. It is difficult to diagnose, but new scientific discoveries are making early diagnosis easier. Treatment can provide effective ways to manage symptoms and improve quality of life.

What to know about late-stage hepatitis C

Hepatitis C is a viral infection that can cause substantial liver damage, particularly in the later stages. The treatment and outlook will depend on the progression of the disease. Learn more here.

What to know about gallbladder removal

A doctor may recommend gallbladder removal if other treatments do not provide relief from the symptoms of gallstones. Learn about the procedure and recovery here.

Anticholinergic drugs: What to know

Anticholinergic drugs can help treat a variety of conditions, including chronic obstructive pulmonary disease, bladder conditions, gastrointestinal disorders, and symptoms of Parkinson’s disease. In this article, learn about the different types of anticholinergic drugs and their possible side effects.

'Anti-aging molecule' could improve liver and kidney treatments

Blocking an enzyme that limits the activity of the 'anti-aging molecule' NAD+ could be a way to protect the liver and kidneys from damage, study suggests.

HYPERTENSION NEWS

What to know about high blood pressure during pregnancy

A doctor should monitor high blood pressure (hypertension) during pregnancy to prevent complications for the mother, such as preeclampsia, and the baby. High blood pressure is usually treatable and preventable. Learn about the types, causes, and treatments of high blood pressure during pregnancy here.

Blood pressure medications: Everything you need to know

Blood pressure medications help prevent many serious complications, such as stroke and heart disease. Learn about the types and possible side effects in this article.

Could blue light reduce blood pressure?

According to recent findings, exposing the body to blue light could lower high blood pressure as effectively as taking hypertension medication.

What are the limitations of BMI?

A person can use their body mass index (BMI) to determine whether they have a healthful weight. But, BMI does not take certain factors into account, such as the proportion of fat to muscle. Learn more here.

What is obesity and what causes it?

Obesity is when a person is carrying excessive weight. This puts them at a higher risk of a number of health conditions. Find out more about what obesity is and why it happens.

Common drug may increase lung cancer risk

According to a recent study, a common drug used to treat blood pressure might increase the risk of lung cancer when it is taken over a long period of time.

How much should I weigh for my height and age?

What is a person’s ideal weight, and how do height, age, and other factors affect it? Find out more and use our tools to get a better idea of how much you should weigh.

This unlikely culprit may cause drug-resistant high blood pressure

A study of 475 male veterans with hypertension links higher lead buildup in shin bone to increased risk of drug-resistant high blood pressure.

High blood pressure control with 'exercise in a pill'

Increased body levels of a compound that the liver makes could control high blood pressure without having to exercise or eat less salt, study suggests.

What is perindopril?

Perindopril is an oral tablet used to treat hypertension (high blood pressure). It’s also used to lower the risk of death or heart attack in people with stable coronary artery (heart) disease. Perindopril is available only as a generic drug. Learn about side effects, warnings, dosage, and more.

GENERAL MEDICAL NEWS

Randomized PIVOT trial published in NEJM suggests more IV iron is better.

NEJM (Macdougall): Conclusions: Among patients undergoing hemodialysis, a high-dose intravenous iron regimen administered proactively was noninferior to a low-dose regimen administered reactively and resulted in lower doses of erythropoiesis-stimulating agent being administered.

Increased mortality with citrate-containing dialysate - HDF fluid in France.

LeMonde: (in French -- paste this link into Google translate) ...les patients traités par un liquide de dialyse (ou dialysat) au citrate présenteraient une surmortalité de 40 % par rapport à ceux traités avec d’autres produits plus anciens à l’acétate ou à l’acide chlorhydrique (HCl).........Tel est le principal constat d’une étude rétrospective pilotée par Lucile Mercadal (Inserm, CESP 1018 et hôpital Pitié-Salpêtrière) réalisée avec une équipe de néphrologues et de biostatisticiens français (REIN-Agence de la biomédecine, ABM), à partir des données du registre national REIN. Elle a été présentée le ­3 octobre lors du congrès de la Société francophone de néphrologie, dialyse et transplantation ; elle n’est pas encore publiée.

Test detects presence of cancer in blood samples based on DNA methylation.

Medical Device Network: Researchers at University of Queensland in Australia have created a new diagnostic test that can identify the presence of a tumour in the body based on a unique, DNA nanostructure that appears to be common to all types of cancer.

Akkermansia gut bacteria and their role in insulin resistance and aging.

Orlando Sentinel: First, they documented that the guts of older animals had markedly smaller populations of A. muciniphila than the guts of young animals, and that as A. muciniphila became more scarce, so did butyrate, one of the gut’s key protectors. The deficiency of these two substances caused the mucous walls of the of the aged animals’ intestines to thin and grow leaky. That corrosive process unleashed a chain of events that touched off inflammation, prompted an immune response and, in a final step, increased insulin resistance.

KidneyX prize competition now open: Application deadline Feb 28, 2019

Phase 1 submission period open now..................... Phase 1 submission period ends: February 28, 2019, 5:00 p.m. ET.............. Phase 1 Awardees announced by: April 30, 2019............................. Phase 2 begins: April 15, 2019................................... In Phase 1, we are looking for designs of solutions that will address at least one of the following areas:......................... Replicating Kidney Functions (Blood Filtration, Electrolyte Homeostasis, Fluid Regulation, Toxin Removal and Secretion, and/or Filtrate Drainage and Connectivity).................................. Improving Patient Quality of Life (e.g., minimizing burden on the family and care partner(s), reducing disease and treatment complications, increasing mobility and physical activity)...................................... Improved renal replacement therapy access (vascular or peritoneal access) Addressing engineering challenges (e.g., preventing clotting, bleeding, and infection in vascular circuit and associated devices)............................ Ancillary technologies................... Biomaterials development.................... Biological and Immunological modulation..................... Biosensor development and other safety monitoring functions................

AKI and CRRT 2019 Conference, Feb 26 -- March 1, 2019, San Diego, CA

The learning objectives for this conference are as follows: 1. Describe the recent advances in the pathophysiology and management of critically ill patients with a focus on sepsis, multi-organ failure, infections, lung and kidney injury in different settings..................................... 2. Discuss the best ways to identify, treat and follow up patients with acute kidney injury (AKI) resulting from different causes utilizing biomarkers, imaging and lab studies and applying educational tools to raise awareness of AKI......................... 3. Describe the principles and practice of renal replacement techniques including CRRT, IHD and plasma exchange and demonstrate how to setup and use these techniques for managing critically ill patients.

Donate to easy water for African villages using hollow-fiber technology

Easy water: Providing clean drinking water in rural areas with contaminated water sources and no power: repurposing reprocessed hemodialyzers. Easy Water for Everyone (EWfE), a US NGO, brings an innovative water-purifying device to isolated villages that have no electricity or other power supply to filter the villages’ contaminated water from rivers, streams, lakes, wells and boreholes, and changes it into pure water ready to drink!

Recovery from coma predicted by artificial intelligence and eye scans.

South China Morning Post: At least seven patients in Beijing who doctors said had “no hope” of regaining consciousness were re-evaluated by an artificial intelligence system that predicted they would awaken within a year.

European funders ban publication in paywall-protected scientific journals.

Science (Martin Enserink): Frustrated with the slow transition toward open access (OA) in scientific publishing, 11 national funding organizations in Europe turned up the pressure today. As of 2020, the group, which jointly spends about €7.6 billion on research annually, will require every paper it funds to be freely available from the moment of publication.

CRISPR treatment halts muscular dystrophy in dogs.

WIRED: His team prepared for the worst -- ”anaphylaxis, liver toxicity, an inflammatory immune response” but in the end they saw no adverse effects. Instead they saw puppies who could play again.

Protein involved in nematode stress response identified

(University of Illinois College of Agricultural, Consumer and Environmental Sciences) When humans experience stress, their inner turmoil may not be apparent to an outside observer. But many animals deal with stressful circumstances -- overcrowded conditions, not enough food -- by completely remodeling their bodies. These stress-induced forms, whether they offer a protective covering or more camouflaged coloration, can better withstand the challenge and help the animal survive until conditions improve.

NSU researchers uncover genetic marker, predictor of early relapse in pediatric ALL

(Nova Southeastern University) Researchers recently discovered that by testing the level of NER (nucleotide excision repair) gene expression, pediatric oncologists can determine the likelihood of early relapse (less than three years) in their acute lymphoblastic leukemia (ALL) patients. This

Mass spectrometry sheds new light on thallium poisoning cold case

(University of Maryland) In 1994, Chinese university student Zhu Ling began experiencing stomach pain, hair loss and partial paralysis. By the time doctors diagnosed Ling with thallium poisoning about four months later, she was in a coma. Two decades after the poisoning, Richard Ash--an associate research scientist in the University of Maryland's Department of Geology--used mass spectrometry to analyze several of Ling's hairs collected in 1994 and 1995 and established a timeline of her poisoning.

Face masks may protect hog farm workers and their household members from staph bacteria

(Johns Hopkins University Bloomberg School of Public Health) Face masks appear to provide important protection against drug-resistant Staphylococcus aureus bacteria for hog farm workers and for household members to whom they might otherwise transmit the bacteria, according to a study led by scientists at Johns Hopkins Bloomberg School of Public Health.

Fitness instructors' comments shape women's body satisfaction

(Northwestern University) A new Northwestern University study found that while exercise, in this case, a 16-minute conditioning class, generally improved women's mood and body satisfaction, women felt even better if the instructor made motivational comments that focused on strength and health instead of on losing weight or changing the appearance of one's body.

Collagen nanofibrils in mammalian tissues get stronger with exercise

(University of Illinois College of Engineering) A recent experimental study conducted by researchers at the University of Illinois at Urbana-Champaign, Washington University in St. Louis, and Columbia University on nanoscale collagen fibrils reported on, previously unforeseen, reasons why collagen is such a resilient material.

Genetically modified pigs resist infection with the classical swine fever virus

(PLOS) Researchers have developed genetically modified pigs that are protected from classical swine fever virus (CSFV), according to a study published December 13 in the open-access journal PLOS Pathogens by Hongsheng Ouyang of Jilin University, and colleagues. As noted by the authors, these pigs offer potential benefits over commercial vaccination and could reduce economic losses related to classical swine fever.

Study finds sewage bacteria lurking in Hudson river sediments

(Earth Institute at Columbia University) A new study shows that fecal bacteria from sewage are living in far greater quantities in near-shore sediments of the Hudson River than in the water itself. The river's pollution levels are generally monitored based on samples of clear water, not sediments, so the findings suggest that people stirring up the bottom while wading, swimming or kayaking may face previously unrecognized health risks.

MON 810 and NK603 GM Maize: No effects detected on rat health or metabolism

(INSERM (Institut national de la santé et de la recherche médicale)) A diet based on MON 810 or NK603 transgenic maize does not affect the health or metabolism of rats, under the conditions of the GMO 90+1 project1. This unprecedented study performed by a research consortium led by Inra brought together a number of partners2, including Inserm. The research was performed as part of the Risk'OGM program funded by the French Ministry of Ecological and Inclusive Transition.

Megacity traffic soot contributes to global warming

(Leibniz Institute for Tropospheric Research (TROPOS)) Soot from road traffic in emerging countries can reach high altitudes, where it can be transported over long distances and thus contributes to global warming. The reduction of pollutants from road traffic such as soot particles from diesel cars should therefore have high priority in order to both protect the health of the population in the growing conurbations of emerging countries and reduce global warming, wrote a an international research team in Atmospheric Environment.