KIDNEY / NEPHROLOGY NEWS

High-Dose Influenza Vaccination May Benefit Transplant Recipients

Double-dose influenza vaccine is safe and may increase antibody response in solid-organ transplant recipients

Ultrasound Predicts Successful AVF Maturation in HD

In a study, arteriovenous fistula blood flow, diameter, and depth were the most informative parameters.

High Blood Pressure of Pregnancy Tied to Dementia Later in Life

Up to 5 percent of pregnant women develop pre-eclampsia, which is tied to an increased risk of dementia in later years.

THE ASN FOUNDATION FOR KIDNEY RESEARCH ENDOWS FIVE CAREER DEVELOPMENT GRANTS

In 2016, the ASN Foundation for Kidney Research launched the Securing the Future Campaign with the goal to endow the Career Development Grants Program. The campaign has since raised more than $22 million through generous contributions from industry, individual donors, and the American Society of Nephrology (ASN).

AMERICAN SOCIETY OF NEPHROLOGY ANNOUNCES NEW JOURNAL: KIDNEY360

To further its mission of facilitating timely and broad dissemination of kidney science, the American Society of Nephrology (ASN) today announced an addition to its journal portfolio, Kidney360. The journal will available online monthly beginning January 2020.

Obstructive Sleep Apnea May Increase Gout Risk

People with obstructive sleep apnea continued to be at higher risk of developing gout after the first year of obstructive sleep apnea diagnosis.

Basic Concepts in Nocturia

International Continence Society (ICS) standards offer useful guidance for nocturia management, according to the authors of a new report.

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound examination may be used to detect crystal deposition in the renal medulla in patients with tophaceous gout.

Sitagliptin Better for Glycemic Control in T2D With Renal Impairment

Study results indicated that sitagliptin showed greater glycemic efficacy than dapagliflozin treatment.

Clinical Gout-Related Benefits Not Seen With Lesinurad Combo Tx

Although a combination of lesinurad 200 mg and xanthine oxidase inhibitor therapy was effective and well-tolerated among patients with gout, clinical gout-related benefits were not improved.

TMVR Benefits Hold Firm in Post-Market Registry (CME/CE)

(MedPage Today) -- Do data point to a future 'transcatheter toolbox' for mitral disease?

Multivessel PCI Not Best in Cardiogenic Shock

(MedPage Today) -- Trial data show mortality disadvantage versus treating culprit lesions only

ASN 2017: The Future of Personalized Nephrology

(MedPage Today) -- Tissue engineering, drug discovery challenges among highlight topics

10 Questions to Challenge Your Medical News Savvy

(MedPage Today) -- Weekly News Quiz: October 20-26

Surgical Weight Loss; Low hs-cTNT Still Risky; VAD Before Pediatric Transplant

(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week

EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

(MedPage Today) -- News and commentary from the endocrinology world

For SAVR, Afternoon Tops Morning for Surgical Safety (CME/CE)

(MedPage Today) -- Circadian genes appear to interact with ischemia-reperfusion injury effects

Robotic-Assisted Surgery Adds Time, Costs Without Affecting Outcomes (CME/CE)

(MedPage Today) -- No improvements compared with laparoscopic procedures in kidney removal and rectal cancer

RAS Blockade After TAVI Tied to Better Outcomes (CME/CE)

(MedPage Today) -- Patients with severe aortic stenosis see reduced all-cause mortality

Borderline Pulmonary Hypertension Tied to Mortality Risk

(MedPage Today) -- Small increases in pressure might signal left heart failure, not early PAH

Can you take too much magnesium?

Magnesium is essential for health, but taking too much can cause problems, including digestive issues, lethargy, and an irregular heartbeat. In rare cases, an overdose can be fatal. Learn more here.

What can make urination painful?

There are many possible causes of painful urination, or dysuria, including bacterial infections and health conditions that place extra pressure on the bladder. Fortunately, most of these potential causes are highly treatable. Learn more about 10 causes of dysuria here, as well as when to see a doctor.

Study overturns what we know about kidney stones

New research uses cutting-edge technology to study kidney stones. The findings change what we know about their nature, composition, and behavior.

Treating urinary tract infections with Cipro

Cipro is an antibiotic that doctors use to treat urinary tract infections (UTIs). For Cipro to work, people must take the full course of the drug and follow their doctor's instructions. But some people may be at risk of severe side effects if they take Cipro, and they may need to consider alternatives. Learn more here.

Urologic conditions lead to depression, sleep issues in men

Physicians need to be aware that men with urologic conditions often have depression and sleep problems and should refer them appropriately, says a study.

Vitamin B-3 may treat and prevent acute kidney injury

New research shows that raising vitamin B-3 levels may benefit patients who have undergone major surgery and are at risk of developing acute kidney injury.

What are the symptoms of a UTI in older adults?

Urinary tract infections (UTIs) can affect people at any age. However, UTIs are one of the most common causes of infection in older adults. Symptoms of a UTI in older adults may include restlessness, agitation, and confusion. UTIs are treatable with medication. Learn more about UTIs in seniors here.

How to do pelvic floor exercises

The pelvic floor is a set of muscles that supports pelvic organs, including the bladder and bowel. These muscles aid urinary control, continence, and orgasm. In this article, learn how to do four exercises that can help strengthen the pelvic floor, including bridge and squats. We also cover which exercises to avoid.

What to do about an evaporation line on a pregnancy test

An evaporation line on a pregnancy test is a faint, non-colored line that may appear if a person uses the test incorrectly. In this article, learn to tell the difference between an evaporation line and a positive test result. We also describe how pregnancy tests work and how to prevent evaporation lines from appearing.

What are the symptoms of late stage bladder cancer?

The symptoms of stage 4 bladder cancer include tiredness, weakness, and pain. Stage 4 is the most advanced stage of cancer. The standard treatment for late-stage cancer is chemotherapy, but treatment will often focus on palliative care. Learn more about the symptoms of stage 4 bladder cancer and the survival rate here.

HYPERTENSION NEWS

High blood pressure control with 'exercise in a pill'

Increased body levels of a compound that the liver makes could control high blood pressure without having to exercise or eat less salt, study suggests.

What is perindopril?

Perindopril is an oral tablet used to treat hypertension (high blood pressure). It’s also used to lower the risk of death or heart attack in people with stable coronary artery (heart) disease. Perindopril is available only as a generic drug. Learn about side effects, warnings, dosage, and more.

High blood pressure breakthrough: Over 500 genes uncovered

The world's largest genetic study of hypertension finds that the number of genetic loci involved is three times larger than previously thought.

Inhaled blood pressure drug could prevent panic attacks

New research suggests that a drug commonly used for hypertension could be used as a quick-acting nasal spray to prevent anxiety attacks.

Can a 16-week lifestyle intervention impact blood pressure?

A recent study demonstrates that simply changing diet and increasing exercise can significantly reduce blood pressure in just 16 weeks.

Cardiovascular disease: Study finds best drugs for prevention

A large cohort study finds out which treatments work best to prevent cardiovascular events in individuals with hypertension and other risk factors.

High blood pressure? Turn up your thermostat

The temperature of your house might influence your blood pressure. A new report suggests that cooler houses may worsen hypertension.

New 'triple pill' could eliminate high blood pressure

Hypertension is very common, and it's a major cardiovascular risk factor. An innovative 'three in one' pill may help treat it more easily and effectively.

E-counseling can lower blood pressure, heart disease risk

New research shows that virtual counseling, when added to medical therapy, lowers high blood pressure and heart disease risk in people with hypertension.

Is it true that 'healthy obesity' boosts death risk?

New research questions whether metabolically healthy obesity — obesity without diabetes, hypertension, or high cholesterol — actually increases mortality.

GENERAL MEDICAL NEWS

Donate to easy water for African villages using hollow-fiber technology

Easy water: Providing clean drinking water in rural areas with contaminated water sources and no power: repurposing reprocessed hemodialyzers. Easy Water for Everyone (EWfE), a US NGO, brings an innovative water-purifying device to isolated villages that have no electricity or other power supply to filter the villages’ contaminated water from rivers, streams, lakes, wells and boreholes, and changes it into pure water ready to drink!

Recovery from coma predicted by artificial intelligence and eye scans.

South China Morning Post: At least seven patients in Beijing who doctors said had “no hope” of regaining consciousness were re-evaluated by an artificial intelligence system that predicted they would awaken within a year.

European funders ban publication in paywall-protected scientific journals.

Science (Martin Enserink): Frustrated with the slow transition toward open access (OA) in scientific publishing, 11 national funding organizations in Europe turned up the pressure today. As of 2020, the group, which jointly spends about €7.6 billion on research annually, will require every paper it funds to be freely available from the moment of publication.

CRISPR treatment halts muscular dystrophy in dogs.

WIRED: His team prepared for the worst -- ”anaphylaxis, liver toxicity, an inflammatory immune response” but in the end they saw no adverse effects. Instead they saw puppies who could play again.

Bacteria becoming tolerant to high concentrations of alcohol in hand sanitizers.

NPR: "To our knowledge this was the first time anyone had shown hospital bacteria becoming tolerant to alcohols," says Timothy Stinear, a coauthor of the study and a researcher at the University of Melbourne's Doherty Institute for Infection and Immunity.

Pharmacologic approach to weight loss that prevents food absorption.

UPI (Allen Cone): "We envision a pill that a patient can take before a meal that transiently coats the gut to replicate the effects of surgery," co-senior author Dr. Jeff Karp, a bioengineer and principal investigator at BWH, said. "Over the last several years, we've been working with our surgical colleagues on this idea and have developed a material that meets an important clinical need." Researchers are now testing LuCl in diabetic and obese rodents, measuring it's short- and long-term effects as an alternative to gastric bypass.

NKF 2018 Spring Clinical Meeting abstracts (.pdf)

NKF Spring Clinical Meeting 2018 abstracts

ERA-EDTA Copenhagen meeting newsletters

ERA-EDTA: Links can be found here to the initial 3 post-congress newsletters, as well as to the accepted abstracts.

CDC issues alert re warfarin coagulopathy and synthetic cannabinoids

CDC: What Do Health Care Providers Need To Do? ............ Healthcare providers should maintain a high index of suspicion for vitamin K-dependent antagonist coagulopathy in patients with a history of synthetic cannabinoids (e.g., K2, Spice, and AK47) use:.................Presenting with clinical signs of coagulopathy, bleeding unrelated to an injury, or bleeding without another explanation; some patients may not divulge use of synthetic cannabinoids...................Presenting with complaints unrelated to bleeding (e.g., appendicitis).

Renal Disease and Electrolyte Course, Aspen, CO; July 23-27, 2018

University of Colorado: Registration: To register visit http://medschool.ucdenver.edu/cme or contact Pam Welker at (303)724-3551 or at pam.welker@ucdenver.edu

GA4GH and ELIXIR release Beacon API v1 with increased security measures

(Global Alliance for Genomics and Health) ELIXIR and the Global Alliance for Genomics and Health (GA4GH) have announced the release of the Beacon API v1 -- a data discovery protocol that allows users to determine the presence or absence of a particular allele in a dataset, without disclosing any further data differentiating the individuals it contains.

Marijuana use might lead to higher risk of stroke, World Stroke Congress to be told

(Heart and Stroke Foundation of Canada) A five-year study of hospital statistics from the United States shows that the incidence of stroke has risen steadily among marijuana users even though the overall rate of stroke remained constant over the same period.

Huge variations between countries in time for reimbursement decisions on new cancer drugs

(European Society for Medical Oncology) Some European countries take more than twice as long as others to reach health technology assessment (HTA) decisions to reimburse new cancer drugs following their approval by the European Medicines Agency (EMA). The average decision time is longer than one year in some countries, according to a study to be reported at ESMO 2018 Congress.

Why some cancers affect only young women

(Université de Genève) Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as 'mucinous cyst,' has strange similarities with another mucinous cancer, affecting the ovaries. By conducting large-scale analyses of genomic data, researchers at the University of Geneva and at the University Hospitals of Geneva have provided an answer: both tumors originate from embryonic germ cells.

Scientists find brain signal that might help us judge the holiday buffet

(Johns Hopkins University) Neuroscientists have found a brain region that appears to be strongly connected to food preference decisions, like what to choose from a buffet line or potluck table.

Src regulates mTOR, a major player in cancer growth

(Baylor College of Medicine) This study shows that Src is necessary and sufficient to activate mTORC1 and offers the possibility to develop novel approaches to control cancer growth.

With a microbe-produced toxin, bacteria prove old dogs can learn new tricks

(University of Washington Health Sciences/UW Medicine) In the ongoing chemical battles among bacteria and their microbial neighbors, a new toxin has been uncovered. This unfamiliar toxin behaves in a familiar way. Its actions against other bacteria resemble the mechanisms of cholera, pertussis and diphtheria toxins. Some bacteria deploying this toxin have safeguards against self-poisoning.

Salk professor named one of TIME magazine's '50 Most Influential People in Health Care'

(Salk Institute) Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory, has been named one of TIME magazine's 50 most influential people in healthcare for his scientific innovations in addressing the shortage of human organs for transplant.

$5.1 million grant will fund research to develop a stem cell-based therapy for blinding eye condition

(University of California - Los Angeles Health Sciences) Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the Stein Eye Institute have been awarded a $5.1 million grant from the California Institute for Regenerative Medicine to advance the development of a novel therapy for blinding retinal conditions.

$5 million NSF grant will help researchers show the impact of their work

(University of Missouri-Columbia) The National Science Foundation has awarded the University of Missouri a $5.2 million grant over five years to establish the Advancing Research and its Impact on Society (ARIS) Center at Mizzou. It will advance the practice of translating scientific research to the public through educational outreach and community engagement.